By Fowler R.H., Milne E.A.
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The authors concluded that mating within clades in C. albicans must be extremely rare. e. isolates from multiple MLST clades) from different clonal lineages and this may have given the appearance of high levels of recombination, and therefore, mating in the C. albicans population. The study of haplotypes also revealed that loss of heterozygosity was a common phenomenon in C. albicans, however, selective pressure maintained an excess of heterozygosity. The authors suggest that the excess of heterozygosity is globally maintained as it may mask deleterious alleles and that the maintenance of alternative alleles may confer a selective advantage (Bougnoux et al.
2002; Thaweboon et al. 2008; Wang et al. 2006). The majority of other isolates have been identified as C. glabrata and C. parapsilosis (Ben-Aryeh et al. 1995; Negroni et al. 2002). 2). 2). Estimates of gastrointestinal carriage (from faecal samples) in healthy individuals range from 8 to 77% (Bougnoux et al. 2006; Fong 1994; Knoke 1999; Scanlan and Marchesi 2008). However, gastrointestinal carriage rates may actually be as high as 100%, with the highest Candida levels in the duodenum (Kusne et al.
1994). C. albicans was isolated in 40–70% of samples, with other isolates identified as C. parapsilosis, C. glabrata, C. tropicalis and C. krusei (Bougnoux et al. 2006; Kusne et al. 1994; Scanlan and Marchesi 2008). 3 Candida Infections and Modelling Disease 43 Asymptomatic vaginal carriage of Candida species is estimated to occur in approximately 22% of women (Dan et al. 2006; Fong 1994; Pirotta and Garland 2006; Rylander et al. 2004). The majority (~80%) of yeasts isolated are identified as C.